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Mitochondrial Replacement Therapy
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# Mitochondrial Replacement Therapy Portal: Reproduction & Development Stage: Clinical under special regulation Evidence: Early human Template: Intervention Risk: Moderate Reversibility: Irreversible Last reviewed: May 2026 == Summary == Swapping faulty mitochondria to prevent inherited mitochondrial disease has produced babies under strict regulation — a narrow, heritable germline intervention. == Key takeaways == * MRT replaces disease-causing mitochondrial DNA while keeping the parents' nuclear DNA. * It is heritable through the female line, making it a limited form of germline modification. * It is permitted only in a few countries under case-by-case oversight. == How it works == Mitochondria carry their own small genome, and mutations in it cause serious inherited disease. MRT transfers the prospective mother's nuclear DNA into a donor egg with healthy mitochondria, so the child inherits nuclear DNA from both parents and mitochondria from the donor. Because mitochondrial DNA passes down the maternal line, the change is heritable — which is why MRT is treated as a carefully bounded germline intervention rather than a routine fertility procedure. == Status and caution == The United Kingdom created a regulated pathway, and births have been reported there and elsewhere. Follow-up so far is limited but has not shown the feared disease in the children. Open questions remain about carryover of a small amount of faulty mitochondria and long-term outcomes. It is a real, regulated therapy for a specific problem — not a general enhancement tool. == Open questions == * Does residual mutant mitochondrial carryover matter over a lifetime? * Should heritable MRT stay confined to preventing serious disease? == Watchlist == * Long-term child follow-up * Mitochondrial carryover * International regulation == References == * First human birth after spindle transfer — Zhang et al., Reprod Biomed Online, 2017. https://pubmed.ncbi.nlm.nih.gov/28385334/. Reported a child born after mitochondrial replacement. * UK regulatory framework for MRT — HFEA. https://www.hfea.gov.uk/treatments/embryo-testing-and-treatments-for-disease/mitochondrial-donation-treatment/. The regulated pathway that permits mitochondrial donation. == Categories == [[Category:Reproduction & Development]] [[Category:MRT]] [[Category:three-parent IVF]] [[Category:mitochondria]]