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categories: ["foundations", "longevity"]categories: ["foundations", "longevity"]tags: ["machine learning", "drug development", "generative chemistry", "target discovery", "clinical trials", "pharmacology"]tags: ["machine learning", "drug development", "generative chemistry", "target discovery", "clinical trials", "pharmacology"]summary: "The use of machine learning to select drug targets, generate candidate molecules and predict failure, so far demonstrably faster at making compounds than at making medicines."summary: "The use of machine learning to select drug targets, generate candidate molecules and predict failure, so far demonstrably faster at making compounds than at making medicines."updated: "2026-10-29"updated: "2026-10-30"humanEvidence: "AI-derived small molecules have reached phase 1 and 2 trials, with a first phase 3 begun in 2026; sponsors of an mRNA therapy built on algorithm-selected neoantigens report a phase 3 in melanoma met its endpoints, and no drug from either route is approved."humanEvidence: "AI-derived small molecules have reached phase 1 and 2 trials, with a first phase 3 begun in 2026; sponsors of an mRNA therapy built on algorithm-selected neoantigens report a phase 3 in melanoma met its endpoints, and no drug from either route is approved."access: "Platforms are proprietary to pharmaceutical companies or licensed to them, and some models and datasets are public; no molecule designed this way is available outside a trial, though AI-suggested uses of approved drugs are."access: "Platforms are proprietary to pharmaceutical companies or licensed to them, and some models and datasets are public; no molecule designed this way is available outside a trial, though AI-suggested uses of approved drugs are."reversibility: "context"reversibility: "context"lines 147–154 → 147–155132 unchanged lines not shown
operational work includes a manufacturing-document review at Enveda that the company says cut humanoperational work includes a manufacturing-document review at Enveda that the company says cut humanreview time by 89%, and an assessment of clinical-trial plans at Bristol Myers Squibb. Every figurereview time by 89%, and an assessment of clinical-trial plans at Bristol Myers Squibb. Every figureis reported by the companies themselves, and Anthropic describes the work as early and mostlyis reported by the companies themselves, and Anthropic describes the work as early and mostlypreclinical: nothing from it has entered a human trial, and the earliest first-in-human date thepreclinical: for the most part its drugs have not reached human testing, though the Bristol Myerscompany offers, late 2028, is conditional on its candidates continuing to hold up. ItsSquibb work concerns an early-stage drug already in clinical trials. The earliest first-in-human date Anthropic offersfor its own programmes, late 2028, is conditional on its candidates continuing to hold up. Itsfurthest-advanced internal programme, a bispecific antibody for a form of congenital muscularfurthest-advanced internal programme, a bispecific antibody for a form of congenital musculardystrophy, rests on a pilot study in mice whose accompanying technical report states that it was notdystrophy, rests on a pilot study in mice whose accompanying technical report states that it was notpeer reviewed and that the experiments were neither randomized nor blinded.peer reviewed and that the experiments were neither randomized nor blinded.removed, struck through added, underlinedLine numbers count the serialised markdown of each revision, frontmatter included.
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